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Laboratory Information Systems (LIS vs LIMS) for Data Management
November 5, 2025
Modern clinical laboratories and pathology practices produce vast amounts of patient and specimen data daily, so using the best pathology management software to track, store, and report this data is crucial.
Medical laboratories benefit greatly from pathology software solutions that power modern laboratory information systems capable of handling all this information and storage, plus support more efficient clinical lab workflow with features like a robust pathology specimen tracking system.
Pathology lab software aids with sample management, the organization of records, and the automation of laboratory workflow management processes. Moreover, the best laboratory information system software also fully supports modern digital pathology solutions, advanced laboratory billing (lab revenue cycle management) functionality, and direct-to-consumer lab testing.
In this blog post, we’ll review the best features of contemporary pathology lab reporting software and how advanced LIS systems benefit medical labs.
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What is Pathology Management Software?
As mentioned earlier, pathology management software is most commonly represented by laboratory information systems (medical LIS software) and, in some cases, by lab information management system software (lab LIMS).
LIS software platforms, and to a lesser extent, lab LIMS solutions, are essential to any efficient medical laboratory. They manage critical functions, such as data entry, specimen tracking, processing, reporting, and storage.
It’s worth noting that while a laboratory information system (LIS) is specifically designed for medical and clinical workflows, a laboratory information management system (LIMS lab management software) is typically used in non-medical, sample-focused industries such as chemical, pharmaceutical, and food testing.
Even so, some medical laboratories still use LIMS software for pathology operations, which is why the terms LIS and LIMS are sometimes used interchangeably in healthcare settings.
Regardless of terminology, both laboratory software systems play a vital role in improving accuracy, efficiency, and productivity through automation and reliable sample tracking.
Discover More: Differences Between Laboratory Information Management Systems (Lab LIMS) and Laboratory Information Systems (LIS Systems)

Tips on How to Choose the Best Laboratory Information System
There are many LIS systems and laboratory information system companies in the market, and each LIS software vendor’s LIS model has a different setup for information management and clinical lab workflow. When deciding which pathology lab software to invest in, it’s best to consider the following questions:
- Is the lab information system built to handle the workflow processes for this specific lab? Is there an option to customize and align with the laboratory’s specific needs?
- Does the medical LIS software support rules and automation that streamline lab workflow and reduce manual touchpoints?
- Does the LIS system offer full integration with laboratory instruments?
- Will the LIS software also fully support lab billing (laboratory revenue cycle management)? If not, will a separate lab RCM or laboratory billing software be required, and if so, how will that laboratory billing system interface with the lab information system?
- What are the data storage and security options? Is data stored on local servers or in the cloud? Does the LIS system offer scalability to support the labs as the business grows?
- What reporting options does the LIS lab application support, and are these reports customizable? Does it seamlessly interface with electronic health records (EHRs), or enable access through online provider and patient portals?
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Laboratory leaders should define clear objectives before selecting a new LIS laboratory information system to ensure the platform aligns with both current operations and long-term goals.
Forward-thinking decision-makers increasingly recognize the value of a single, integrated LIS software platform that includes built-in laboratory billing functionality and scales with the organization’s growth. This “one source of truth” approach eliminates the confusion and inefficiency that come with juggling multiple lab vendors.
Instead of finger-pointing between disconnected diagnostic lab software systems, the laboratory partners with one trusted LIS software provider that delivers a fully unified medical LIS and lab RCM solution, enabling teams to streamline resources, reduce complexity, and focus on delivering high-quality diagnostic services.
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Core Laboratory Information System Functions and Benefits
Getting the best LIS backed by the right laboratory information system vendors is key to successful clinical and pathology lab management. At their core, laboratory information systems streamline sample tracking management and bring several benefits.
- A modern LIS software with an advanced pathology specimen tracking system helps ensure proper handling and correct testing of the samples being processed within the lab.
- Integrating an advanced medical laboratory information system with EHRs and laboratory instruments removes much of the need for manual data entry. This lab interface system setup reduces human error and the workload on overstretched lab personnel.
- A modern laboratory information system provides secure, convenient access to data and documents online. Built-in security controls ensure that only authorized users can view sensitive information, protecting patient privacy while maintaining compliance and efficiency.
Discover More: What You Need to Know Before Contracting with a Laboratory Information System (LIS) Company
The Best Laboratory Information System Software Supports Efficiency and Scalability
The best laboratory information system software offers more than just enhanced laboratory workflow management capabilities. These advanced pathology lab reporting software solutions boost the growth and performance of testing organizations through additional features that legacy LIS systems simply don’t have.
Using LIS Systems to Report and Analyze
Advanced pathology LIS systems incorporate data analysis, lab report production, and database backup without a separate pathology lab reporting software requirement. LIS systems such as the LigoLab Informatics Platform facilitate integrated reporting and offer custom template formats to fit the needs of each lab and their specific client preferences.
Discover More: How LigoLab's LIS Software Supports Lab Report Customization and Client Preferences
LIS Systems and Functional Pathology Lab Management
A modern medical LIS system goes far beyond automating sample processing. It also streamlines pathology lab management and strengthens team coordination across the organization.
Among the many advantages of an advanced LIS functionality, lab workflow optimization often delivers the greatest impact on performance and profitability. By standardizing procedures and automating routine tasks, modern LIS software helps laboratories improve efficiency, maximize staff productivity, and consistently produce accurate, reliable clinical results.
Discover More: How Laboratory Information Systems Help Lab Operators Overcome Industry-Wide Staffing Shortages
Medical LIS Systems and Compliance
The most effective LIS medical solutions simplify compliance by automating and standardizing processes that align with regulatory requirements. A strong example is LigoLab’s all-in-one informatics platform, which streamlines quality control (QC) and quality assurance (QA) through consistent workflows that promote accurate testing, precise reporting, and reliable laboratory operations.
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LigoLab’s QC module enables real-time monitoring of control data, automatically sending alerts when abnormal readings occur. Its QA framework tracks every workflow step to ensure all laboratory operations are performed consistently, safely, and in full compliance with established standards.
Learn More: A Detailed Look at How Modern Laboratory Information Systems Fully Support Quality Control
Integrated Laboratory Billing Solutions
Laboratory revenue cycle management often involves multiple administrative steps. Because of this, most labs use lab billing software to handle medical bill generation, claims and payment processing, and revenue collection.
However, a modern pathology information system can incorporate the latest laboratory billing solutions within the LIS system’s workflow so financial services are automated and interwoven alongside laboratory information system functions.
This enables labs to have more control over their finances and collect lab billing and insurance information as soon as the order is received, thereby optimizing net collections. Labs benefit from enhanced transparency, full payment for their services, and much fewer denials.
Discover More: LIS System and Lab Billing Data are Interdependent, So Why not Integrate Both into ONE Powerful Informatics Platform?
LIS Systems and Technical Support
Today’s advanced pathology LIS systems can be tailored to fit a laboratory’s specific size, workflow, and procedural preferences.
To fully leverage the capabilities of a new medical LIS software platform, reliable and accessible technical support is essential. Ongoing assistance ensures that laboratory directors, managers, and technologists can use all laboratory information system functions effectively and maintain smooth day-to-day operations.
However, not all LIS vendors provide the same level of service. Some limit support access or charge additional fees, creating unexpected costs. For labs that value continuous partnership and unlimited support, it’s critical to confirm these details upfront when evaluating and negotiating with potential LIS system providers.
Discover More: Why Medical Labs Should Consider Deeper Alignment with Their LIS System Partner

Final Thoughts on Pathology Management Software and LIS Systems
Modern laboratory information systems, such as the LigoLab Informatics Platform, offer the latest technological solutions to managing large amounts of patient and specimen data.
This capability lies at the heart of a laboratory information system’s core functions, enabling organizations to deliver better patient care, stand out in a competitive market, scale efficiently, and operate with greater compliance and profitability.
To learn more about LigoLab, a modern LIS company that produces advanced pathology lab report software for growing clinical labs and pathology groups, contact a product specialist and request a brief introductory call.
Step into the Future: Speak with a LigoLab Specialist Today!





