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The Best LIS Systems are Comprehensive and Laboratory-Specific
June 23, 2025
For independent anatomic pathology groups and clinical laboratories to successfully navigate today’s challenging times, lab operators in those facilities need LIS laboratory information system software that is functional, flexible, and configurable.
Today’s medical LIS system software must constantly evolve to the needs of clients, keeping pace with change resulting from new pathology lab management technologies and discoveries. To accomplish this, they must have a high degree of control, support, and best practice guidance from modern laboratory information system companies that understand the complexities inherent in today’s medical lab environment.
Learn More: Boosting Operational Efficiency: How LigoLab Transforms Laboratory Workflows
Which LIS Model is the Best Laboratory Information System for Long-Term Success?
What are the best laboratory information system software solutions out there, and what makes them so?
Let’s examine the options.

A few years ago, the College of American Pathologists (CAP) commissioned reputable pathologists from across the country to compare two laboratory information system models to see which one was most advantageous.
The physicians involved in the study evaluated and compared a dedicated end-to-end laboratory information system (LIS) with a modular diagnostic lab software component embedded within an enterprise electronic health record (EHR) platform.
The doctors were not compensated for their work or findings.
The authors concluded that the best LIS medical systems are consistently end-to-end lab information system solutions that fully support laboratory billing (lab revenue cycle management).
The study highlighted several clear advantages for the dedicated LIS model, including a defined oversight structure, tailored laboratory configurations, robust laboratory information system functions, and direct access to LIS software vendors.
Learn More: What You Need to Know Before Contracting with a Laboratory Information System (LIS) Company
Defending the LIS: Study Pushes Back Against EHR-Driven Consolidation
The study represents a timely counterpoint for hospitals and health systems pressuring medical laboratories to abandon their dedicated laboratory information systems in favor of solutions bundled with enterprise electronic health records.
Motivated by tight budgets and consolidation trends, many institutions have pursued EHR-integrated lab modules under the assumption that they offer cost savings, easier maintenance, and smoother implementation. However, the study raised concerns that such decisions were often made with little to no input from the very pathologists who rely on these pathology lab software solutions.
Historically underappreciated, pathologists play a vital but often invisible role in patient care. Thankfully, that’s beginning to change. With growing demand for diagnostic testing, driven by an aging population and the rise of personalized medicine, laboratory professionals are gaining recognition as essential players in delivering timely and accurate medical decisions.
The study reinforces the value of dedicated LIS pathology platforms, especially in an era where lab performance is directly tied to healthcare quality and outcomes.
Learn More: Best Pathology Lab Reporting Software - 2025 Buyers Guide and Checklist

Learn More About LigoLab’s Advanced Medical Laboratory Information System Software
At LigoLab, we’ve been helping medical labs grow and thrive for nearly two decades by continually enhancing our agile and nimble approach to LIS medical solutions.
The all-in-one LigoLab Medical LIS & Lab RCM Informatics Platform was designed and developed by pathologists and laboratorians to promote efficiencies and streamline clinical laboratory management and lab workflow while keeping lab operators in control with pathology software technology that can be tailor-made to fit their lab’s unique needs and goals.
Industry Insights: Bridging the Gap in Modern Laboratories: Why a Comprehensive Digital Platform Outperforms a Basic Lab Information System
The LigoLab platform is backed up by the deep domain experience acquired through years of working closely with our client labs, and we offer responsive and unlimited 24/7 customer service and support.
Learn More: Stability and Performance: The Two Most Important Aspects of a Modern Laboratory Operation
LigoLab also offers flexible LIS model pricing tiers that eliminate large, upfront licensing fees. This shared-risk philosophy empowers laboratories to scale efficiently without financial barriers hindering growth. Unlike traditional LIS lab vendors and their legacy LIS systems, LigoLab actively partners with labs, responding quickly and collaboratively to new opportunities for expansion, strategic partnerships, and operational growth.
Scalable LIS System & Lab Billing Platform Tiers Built for Every Stage of Lab Growth
LigoLab’s tiered structure aligns with the evolving needs of medical laboratories. Each tier supports increasing levels of complexity and functionality, providing a clear and flexible roadmap for long-term growth, all within a single, powerful, and unified informatics platform.
Here’s a summary of the four tiers:
Essential Tier - A streamlined, user-friendly LIS software solution tailored to smaller pathology groups, molecular labs, and reference laboratories. It covers core operational needs with simplicity and ease of use.
Professional Tier - An advanced LIS lab platform designed for growing organizations. It includes enhanced laboratory workflow management, robust reporting and analytics, seamless integration with external healthcare systems, and support for complex order workflows.
Advanced Tier - Designed for high-volume, high-throughput laboratories, this tier delivers advanced LIS lab automation, streamlined efficiency, powerful informatics capabilities, and priority support for mission-critical operations.
Enterprise Tier - The ultimate LIS system software solution for large regional and national laboratories. It delivers total integration across departments and sites, maximum scalability, and fully customizable workflows to support even the most complex lab environments.
As a comprehensive all-in-one pathology lab software solution, the LigoLab platform goes beyond traditional pricing and core clinical lab workflow management to provide all the supporting modules a laboratory needs (including the financial ones).
The LigoLab platform drives business growth, reduces labor costs, and increases revenue while optimizing client services and patient care.
Case Study: From Launch to Lift-Off: Highlighting Goldfinch Laboratory’s Formula for Rapid Growth

Laboratory Information System Software References
Archives of Pathology and Laboratory Medicine: Stand-alone Laboratory Information Systems Versus Laboratory Modules Incorporated in the Electronic Health Record
Medical Laboratory Observer: It’s Time to Redefine the LIS

Reimagining Modern LIS Systems: One Platform, Limitless Potential
At LigoLab, we didn’t just build another lab information system; we redefined what LIS software can do. Our all-in-one LIS system and lab revenue cycle management (lab RCM) platform is a next-generation pathology lab reporting software solution that seamlessly combines powerful automation, intuitive features, and full interoperability. It’s designed to help independent labs grow, adapt, and thrive in today’s rapidly evolving LIS healthcare environment.
Unlike legacy pathology LIS systems that rely on fragmented workflows and inefficient manual processes, LigoLab’s fully integrated platform eliminates workarounds, reduces errors, and streamlines operations across every department. From pathology and molecular diagnostics to microbiology and genomics, LigoLab empowers labs to operate smarter, scale faster, and deliver better patient outcomes.
For nearly two decades, over 300 labs nationwide have trusted LigoLab to modernize their operations and lead with innovation. Now it’s your turn to experience the LigoLab advantage.
Ready to see what’s possible?
Connect with a LigoLab product specialist today and schedule your personalized demo. See how our LIS software can be tailored to your lab’s unique needs.
Start your transformation today – contact us to learn more!
