Industry Insights
Examining the Pros and Cons of Cloud-Based LIS System Solutions
September 15, 2025
I’d like to highlight a recent article from Clinical Lab Products entitled “Is a Cloud-Based LIS Solution the Best Choice for Your Lab’s Future?”
I’m using this forum to share key points from the article so clinical lab leaders are properly informed and poised to make the best decision for their lab operations as they deal with the ongoing challenges of today and look toward the future.
After sharing key points, I’ll highlight LigoLab’s flexible approach to server locations and explain why our enterprise LIS laboratory information system software platform with embedded and advanced laboratory billing solutions offers such flexibility.
White Paper: The Connected Laboratory - Leveraging Medical LIS & Lab RCM Workflows to Grow Your Business
Key Points Summary:
Cloud-Based vs. On-Premises Laboratory Information System Software Solutions
Cloud-Based LIS Systems:
- Software and data are stored on third-party servers (e.g., Microsoft Azure, AWS).
- Accessible via the internet, offering flexibility, scalability, and remote accessibility.
- Typically better suited for smaller labs due to lower infrastructure requirements and pay-as-you-go pricing.
On-Premises LIS Systems:
- Software and data are stored on internal servers and managed by in-house IT staff.
- They offer full control over data but lack scalability and accessibility.
- Preferred by larger labs with existing infrastructure or those prioritizing data control.
Advantages of Cloud-Based LIS Systems
- Flexibility & Scalability: Resources can be scaled up or down based on demand without hardware investments.
- Recovery & Continuity: Robust disaster recovery solutions, including automatic backups and geo-replication.
- Cost Efficiency: The pay-as-you-go model reduces upfront and ongoing costs compared to on-prem systems.
- Accessibility: Remote access and collaboration are enabled with an internet connection.
- Security: Advanced cybersecurity often exceeds the capabilities of a single lab to manage on its own.
- Innovation: Continuous integration of emerging technologies like AI and advanced analytics.
Discover More: How AI Can Propel Medical Laboratories into a New Era of Growth
Challenges of Cloud-Based LIS Systems
- Potential loss of connectivity and server downtime.
- Concerns about data security and control.
- These LIS systems may not meet the needs of labs with highly sensitive data or strict regulatory requirements.
Factors Influencing the Decision
- Smaller Labs: Cloud-based LIS systems are ideal for cost-effectiveness and minimal IT infrastructure needs.
- Larger Labs: They may favor on-prem LIS system solutions due to existing investments and the need for greater data control.
- Data Sensitivity: Labs with stringent data security concerns may prefer on-prem LIS system solutions.
Industry Expert Perspective
- Dennis Winsten: Advocates for cloud-based LIS systems as the future due to their advantages in accessibility, scalability, and innovation.
- He strongly suggests cloud-based lab information system solutions for smaller labs, but acknowledges that established, larger labs might retain on-premises LIS systems for control and familiarity.
Discover More: The Best Laboratory Information System Companies and the Advantages They Offer to Their Laboratory Clients
Security Considerations
- Winsten emphasizes the importance of working with laboratory information system vendors who provide advanced security features (encryption, audit trails, and monitoring).
- He highlights the ability of cloud-based LIS systems to integrate with cutting-edge security tools that proactively mitigate cyber threats.
Discover More: Is Your Laboratory Information System and Lab Vendor Holding Your Laboratory Hostage?
Conclusion:
While cloud-based laboratory information system software solutions offer significant scalability, cost, and innovation advantages, the choice between cloud and on-premises depends on the lab's size, budget, infrastructure, and data control and security priorities.
Discover More: Comparing the LigoLab Informatics Platform with Legacy Laboratory Information System Software

Modern Laboratory Information Systems: Key to Innovation and Efficiency
In an era of rapid digital transformation, healthcare organizations, particularly clinical laboratories and pathology groups, must embrace innovation to remain competitive. Labs must seek long-term partnerships with laboratory information system companies that offer cutting-edge healthcare LIS technology that’s critical to driving efficiency, improving workflows, and fostering innovation in laboratory medicine.
Comprehensive LIS Systems Support from LigoLab
LigoLab is a good example of what’s possible when laboratory information system innovation and unparalleled customer service converge. The forward-thinking LIS company supports cloud-based and on-prem LIS system server solutions with its all-in-one pathology software platform.
LigoLab manages server maintenance, updates, and LIS system configurations for on-prem customers, allowing labs to focus on operations rather than technical challenges.
LigoLab’s platform also fully supports cloud-based lab information system customers, offering seamless integration with third-party cloud server providers.
Discover More: LigoLab’s LIS System Software Offers Server Flexibility
The Role of Modern LIS System Platforms
Modern laboratory information system platforms, such as LigoLab’s all-in-one medical LIS with advanced embedded laboratory billing functionality, offer unrivaled efficiency and functionality compared to legacy LIS systems. These advanced informatics platforms:
- Streamline clinical lab workflow and eliminate bottlenecks.
- Introduce advanced automation in technical and lab billing workflows, effectively addressing staffing shortages and operational costs.
- Enable scalability and market differentiation, helping labs meet customer demands and maintain profitability.
Unlike rigid legacy LIS systems, the best laboratory information system software platforms provide the much-needed flexibility to adapt to diverse laboratory needs and future challenges.
Features of the LigoLab Platform
LigoLab’s LIS lab platform includes modules and tools designed to enhance lab operations:
- Core Modules: Anatomic and clinical pathology, molecular diagnostics, laboratory revenue cycle management (lab RCM), and direct-to-consumer lab testing (TestDirectly).
- Support Engines: Laboratory outreach solutions, sample tracking, quality control/assurance, client portals, inventory management, and business intelligence reporting.
- Scalability: A flexible, all-in-one LIS system that grows with the lab, accommodating increasing volumes and complexity.
By integrating advanced automation, data tracking, and reporting capabilities into the LIS system and lab billing workflow, LigoLab empowers labs to differentiate themselves, improve patient care, and achieve long-term compliance and profitability.
Discover More: Why Integrated LIS System and Lab RCM Software is a Catalyst for Growth
LigoLab: A Leader in LIS Systems
LigoLab has established itself as a trusted partner for hundreds of clinical laboratories and pathology groups. Its comprehensive and highly configurable laboratory information system software platform enables labs to serve physicians and patients better, scale their operations, and achieve financial goals while staying competitive in an evolving industry.
Modern LIS systems are no longer optional but essential for laboratories aiming to thrive in a rapidly changing healthcare landscape. By choosing a flexible, comprehensive solution like LigoLab, laboratories can unlock new opportunities and remain at the forefront of innovation.
Discover More: What Started as a Shared Vision Between Friends Has Become the Definitive Lab Information System Choice for Modern Laboratories
Ready to Tame the Multi-System Chaos in Your Lab Environment?
Ditch the patchwork LIS software solutions of the past and streamline all operations (technical and financial) with an all-in-one informatics platform built to modernize your lab and accelerate growth.